Research in the Calfee Lab has three parallel and complementary areas of focus, all of which share the ultimate goal of deepening our understanding of the pathogenesis of the acute respiratory distress syndrome (ARDS) and sepsis so as to improve prevention and treatment strategies.  Our group’s main focus is on novel approaches to molecular phenotyping of critical illness and advancing precision medicine for ARDS and sepsis, including the identification of molecular subphenotypes.  We also have an interest in the epidemiologic and mechanistic relationship between tobacco products and acute lung injury/ARDS, with recent extensions to air pollution and the acute pulmonary impact of e-cigarette use.  Finally, we are interested in novel treatment strategies for ARDS, sepsis, and related conditions and participate in multiple clinical trials of novel therapies.